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In vivo testing in xenograft mouse models confirmed that UCM 1037 suppressed DX3 tumor growth and demonstrated greater inhibitory activity compared to melatonin alone at the same dose (16 mg/kg) [87]

Threshold and firing frequencies were measured during continuous force ramps from 0 to 100 mN (ramp duration 10 s) and firing frequencies during static force applications (0 to 5, 10, 20, 40, 50, 75, 150 and 200 mN, step duration 10 s

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PLoS One 11 , e0156925 (2016)

Additionally, treatment with GLP-1RA and exendin-4 increased the expression of the calcitonin gene in the thyroids of normal (wild-type) mice